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The authors concluded that while the combination showed limited effectiveness in the overall population, it might offer potential benefits for individuals with particular baseline features [76]
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Beyond the observation, remains the identifications of the causes of these degradation processes, which mostly remain unknown
However, cancer cells can escape cellular ferroptosis by activating or remodeling various signaling pathways, including oxidative stress pathways, thereby limiting the efficacy of ferroptosis-activating targeted therapy
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